Variability of major histocompatibility complex class DQA and DQB genes in the golden jackal (Canis aureus)

Svetličić, Ida (2016) Variability of major histocompatibility complex class DQA and DQB genes in the golden jackal (Canis aureus). Diploma thesis, Faculty of Science > Department of Biology.

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Abstract

Genes within the major histocompatibility complex (MHC) encode receptors that are responsible for processing and presentation of antigens to T lymphocytes, which initiates the adaptive immune response of the organism. Increased variability of MHC gene loci enables identification of a broader range of antigens, and consequently a better defense against pathogens. The variability of the MHC loci is maintained by the balancing selection, which is characterized by a larger number of divergent alleles in the population. MHC genes proved to be a good marker for the study of adaptive evolution of the species and populations. Golden jackal (Canis aureus) is widespread, but so far one of the least studied members of the dog family (Canidae). In this research, I found and described the alleles of the DLA-DQA and DQB MHC class II loci in a sample of 27 jackals from Eastern Europe. I found two alleles per locus, all of which are known from previous research. Despite the small number of alleles found, evolutionary distances indicate a considerable diversity among them. I confirmed the role of balancing selection on maintaining variability of the investigated loci, using the ratio of synonymous and nonsynonymous mutations both on the entire nucleotide sequence, and the particular codons.

Item Type: Thesis (Diploma thesis)
Keywords: MHC, Canis aureus, DRQB, DQA, balancing selection
Supervisor: Galov, Ana
Co-supervisor: Arbanasić, Haidi
Date: 2016
Number of Pages: 42
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 24 Mar 2016 12:49
Last Modified: 24 Mar 2016 12:49
URI: http://digre.pmf.unizg.hr/id/eprint/4621

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