Th1 and Th2 associated chemokines and chemokine receptors in RSV infection

Vojvoda Parčina, Valerija (2016) Th1 and Th2 associated chemokines and chemokine receptors in RSV infection. Doctoral thesis, Faculty of Science > Department of Biology.

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Abstract

RSV (respiratory syncytial virus) is the most common cause of respiratory infections in infants. Development of severe lower respiratory tract infections and frequent reinfections could relate with the simultaneous development of protective Th1 and pathogenic Th2 immune responses. Th1 is represented by predominant IFN-γ and associated with increased CXCL10 and CXCL9 production. Contrary, Th2 is represented by increased IL-4 and CCL17/CCL22 production. We have determined the chemokine profile of children with severe RSV infection, in addition to specific chemokine receptors CXCR3 and CCR4 expression on memory T cells. To confirm type-2 T-cell polarization, we also analyzed CRTh2 receptor expression. Results showed RSV specifically increases CXCL10 and CCL17 levels in acute infection, followed by inadequate immune memory development in terms of higher percentages of type-1 and type-2 TEM cells, and lower percentages of long-living type-1 memory T cells. Failure in the development of appropriate immune memory, together with the presence of both type-1 and type-2 immune response, could play an important role in RSV pathogenesis and reinfections.

Item Type: Thesis (Doctoral thesis)
Keywords: CXCR3/ CCR4/ CRTh2/ memory T cells/ BAL
Supervisor: Bendelja, Krešo
Date: 2016
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Grozdana Sirotic
Date Deposited: 30 Mar 2016 14:17
Last Modified: 30 Mar 2016 14:17
URI: http://digre.pmf.unizg.hr/id/eprint/4658

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