Evolution and function of rodent specific MT transposons

Franke, Vedran (2016) Evolution and function of rodent specific MT transposons. Doctoral thesis, Faculty of Science > Department of Biology.

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Abstract

MT retrotransposons are LTR retrotransposons found specifically in the rodent lineage. After SINE and LINE retrotransposons, MT elements are the third most abundant repetitive class in the rodent genomes. Unlike classical mammalian LTR retrotransposons, the internal sequence of MT elements lacks homology to the retroviral GAG, POL and PRO proteins; rather it contains sets of regulatory sequences. These regulatory sequences enable MT elements to reprogram the transcriptome in an oocyte-specific manner. MT elements are subdivided into five groups, MTA – MTE. An MTC element in the intron 6 of the Dicer 1 gene creates an oocyte specific, truncated Dicer isoform – DicerO. Such truncated isoform has higher processivity for small interfering RNAs, when compared to the somatic isoform, DicerS. Targeted excision of the MTC causes meiotic spindle deformation and female sterility, thereby illustrating its essential function of the retroelement for in mice. In this work I have described the origin and exaptation of MT elements in the rodent lineage.

Item Type: Thesis (Doctoral thesis)
Keywords: Retrotransposon, MT, Oocyte, miRNA, siRNA
Supervisor: Vlahoviček, Kritian
Date: 2016
Number of Pages: 90
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Grozdana Sirotic
Date Deposited: 30 Mar 2016 14:25
Last Modified: 30 Mar 2016 14:25
URI: http://digre.pmf.unizg.hr/id/eprint/4659

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