Tumor markers

Ančić, Anja (2015) Tumor markers. Bachelor's thesis, Faculty of Science > Department of Biology.

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Abstract

Tumor cells or host cells produce certain substances in response to the tumor. Such substances, if measurable in body fluids or tissues of a patient that can serve in distinguishing tumor and healthytissue are called tumor markers. Many studies are trying to develop new and to understand already known markers for brain tumors. Glioma is a type of brain tumor that usually arises from glial cells. Gliomas are divided into classes depending on the agressivnes. The highest, grade IV gliomas are glioblastomas. Glioblastoma is the most common primary brain tumor in adults patients with a average survival 14 months after diagnosis. Potential genes and enzymes that could serve as a glioblastoma tumor markers are O-6-methylguanine-DNA methyltransferase (MGMT), isocitratedehydrogenase genes 1 and 2 (IDH1, IDH2), p53, epidermal growth factor receptor (EGFR), platelet derived growth factor receptor (PDGFR), phosphatase and tensin homologue (PTEN), phosphoinositide-3-kinase (PI3K) and 1p/19q codeletion. Previous studies confirmed the importance of MGMT and IDH1/2 genes in glioblastoma tumorigenesis, while the role of other above mentioned markers still can not be confirmed. Existing markers mostly do not show sufficient specificity that could be used in early diagnosis, but still provide important information that can be used with other diagnostic methods.

Item Type: Thesis (Bachelor's thesis)
Supervisor: Korać, Petra
Date: 2015
Number of Pages: 13
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 13 Apr 2016 10:48
Last Modified: 13 Apr 2016 10:48
URI: http://digre.pmf.unizg.hr/id/eprint/4692

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