Tryptophan-synthase: a multienzyme complex with an intramolecular tunnel

Bošnjaković, Marta (2015) Tryptophan-synthase: a multienzyme complex with an intramolecular tunnel. Bachelor's thesis, Faculty of Science > Department of Biology.

[img]
Preview
PDF
Language: Croatian

Download (1MB) | Preview

Abstract

Tryptophan-synthase is a multienzyme complex, catalyzing the last two steps in the synthesis of tryptophan. Tryptophan is one of the aromatic acids so it shares the beginning of the synthesis with amino acids phenylalanine and tyrosine. It is synthesized by prokaryotes, fungi and plants. Here we describe the structure of tryptophan-synthase, explain in detail mechanism of the reaction at each subunit and explain the transfer of information between them. Moreover, tryptophan-synthase may be used as a model enzyme to understand certain properties that are present in many other enzymes and are important for their efficiency, like allosteric regulation, substrate channeling through the intramolecular tunnel and biochemistry of coenzyme PLP (pyridoxal-phosphate). The understanding of molecular mechanism of this nano-machine, have direct benefits, for example in design of herbicides or drugs against various diseases. Despite the fact that the structure of tryptophan-synthase is known for a quite long time, relatively recently, because of use of more sophisticated methods of research, details of the structure have been revealed. But, there are still certain intermediate structures that are unknown and therefore, further research is needed.

Item Type: Thesis (Bachelor's thesis)
Supervisor: Gruić Sovulj, Ita
Date: 2015
Number of Pages: 20
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 13 Apr 2016 11:07
Last Modified: 13 Apr 2016 11:07
URI: http://digre.pmf.unizg.hr/id/eprint/4696

Actions (login required)

View Item View Item