Induced animal models in physiology and immunology

Derežić, Ivana (2015) Induced animal models in physiology and immunology. Bachelor's thesis, Faculty of Science > Department of Biology.

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Abstract

Number of laboratory animals was increasing during the history as well as number of used species. Today, animals are used to understand basic biology and as test subjects for the development and testing of drugs and other phenomena to improve human health. For practically every known human disease researchers attempt to induce similar aspects of the disease in animals. In order to create these models, animals are subjected to different procedures which include surgeries, traumatic injuries, food, water and social deprivation, viral and bacterial infections, exposing to radiation, chemicals or toxic drugs. Diabetes type I in animals can be induced by glucose analogues, streptozoticin or aloxan, while diabetes type II can be induced by high fat feeding. The ovariectomized rat model is most commonly used in research on postmenopausal osteoporosis. Inflammatory bowel diseses, Crohn´s disease and ulcerous colitis, are induced by chemicals like acetic and trinitrobenzenesulfonic acid, indomethacin and many other. Research into the pathogenesis of psoriasis has been hampered by the lack of a naturally occuring disorder in laboratory animals that mimics the complex phenotype and pathogenesis of the human disease. However, there are some chemicals that can induce certain symptoms which are common in psoriasis. Some central nervous system disease models can be also created. Mice are shown to be good models of schizophrenia, Alzheimer's disease and Parkinson’s disease. There are several ways to induce tumors in laboratory animals which include radiation and chemicals exposures, virus infections and transplantations.

Item Type: Thesis (Bachelor's thesis)
Supervisor: Oršolić, Nada
Date: 2015
Number of Pages: 28
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 13 Apr 2016 11:47
Last Modified: 13 Apr 2016 11:47
URI: http://digre.pmf.unizg.hr/id/eprint/4701

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