Genetics of autoimmune diseases

Fabijanić, Maja (2015) Genetics of autoimmune diseases. Bachelor's thesis, Faculty of Science > Department of Biology.

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Abstract

Autoimmune diseases are very complex diseases that keep affecting more and more people. Since they are the result of genetic disorders and enviromental factors, they appear with a large spectrum of symptoms which makes their characterization and discovering their real cause even more difficult. That is why they are only roughly divided into organ-specific and systemic. Besides cells having disrupted functions, influence of components of complement and cytokines and chemokines is very important in their development and affect symptoms of the diseases. Hashimoto’s thyroiditis, myasthenia gravis and type 1 diabetes mellitus are some of the organ-specific diseases, while systemic lupus erythematosus, rheumatoid arthritis and multiple sclerosis are representatives od systemic autoimmune diseases. Most of the information of their genetic background comes from the genome-wide association studies, however, such research cannot precisely predict which genetic locuses are critical for development of certain diseases, therefore, in further research it will be key to determine which locuses are critical and their functions.

Item Type: Thesis (Bachelor's thesis)
Supervisor: Oršolić, Nada
Date: 2015
Number of Pages: 18
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 13 Apr 2016 12:06
Last Modified: 13 Apr 2016 12:06
URI: http://digre.pmf.unizg.hr/id/eprint/4703

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