The role of thioredoxin in cell adaptation to oxidative stress

Hloušek-Kasun, Andrea (2015) The role of thioredoxin in cell adaptation to oxidative stress. Bachelor's thesis, Faculty of Science > Department of Biology.

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Abstract

Oxidative stress reflects an imbalance between cell oxido-reductive reactions in favour of oxidation. It is a result of uncontroled production of reactive oxygen species. The creation of free radicals can be initiated by exogenous or endogenous factors. Mainly, they are product of mitochondrial oxidative metabolism. Oxidative stress can induce severe macromolecular damage which can be deleterious for the cell. Two molecular systems responsible for protecting cellular macromolecules from damage induced by ROS and elecrofilic species, were identified together in many organisms: thioredoxin and glutathione/glutaredoxin system. The thioredoxin system comprises thioredoxin, thioredoxin reductase and NADPH, and is ubiquitous from Archea to man. The physiological functions of thioredoxins in different types of organisms have evolved from a common fundamental reaction to large number of different specialized functions. Its main and conserved role is to provide hydrogen for various reductive enzymes. Thioredoxin protects cell against oxidative stress by scavenging ROS trough a variety of direct or indirect mechanisms. There is a growing number of its distinct functions and participation in various macromolecular systems that play important role in oxidative stress.

Item Type: Thesis (Bachelor's thesis)
Supervisor: Gruić Sovulj, Ita
Date: 2015
Number of Pages: 24
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 13 Apr 2016 12:54
Last Modified: 13 Apr 2016 12:54
URI: http://digre.pmf.unizg.hr/id/eprint/4709

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