Experimental methods in functional genomics

Mikičić, Ivan (2015) Experimental methods in functional genomics. Bachelor's thesis, Faculty of Science > Department of Biology.

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Abstract

Over the past few years, massively parallel DNA sequencing platforms have become widely available, dramatically reducing the cost of DNA sequencing. The fast and low-cost sequencing approaches not only change the landscape of genome sequencing projects but also usher in new opportunities for sequencing in various applications, among other in functional genomics. The aim of functional genomics studies is to understand the complex relationship between genotype and phenotype on a genome-wide scale. Studies investigate a range of processes such as transcription, translation and epigenetic regulation, in an attempt to answer relevant biological questions. Newly developed techniques, such as RNA-seq, ChIP-seq and 3C-based methods found their use in some of the most massive projects, such as the ENCODE project. The aim of this review was to introduce some of the most common techniques in functional genomics and to explain their possibilities, advances, applications and challenges.

Item Type: Thesis (Bachelor's thesis)
Supervisor: Vlahoviček, Kristian
Date: 2015
Number of Pages: 17
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 14 Apr 2016 10:25
Last Modified: 14 Apr 2016 10:25
URI: http://digre.pmf.unizg.hr/id/eprint/4718

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