Transcription factor c-MYC – key regulator of tumorigenesis

Mojzeš, Anamarija (2015) Transcription factor c-MYC – key regulator of tumorigenesis. Bachelor's thesis, Faculty of Science > Department of Biology.

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Abstract

The c-MYC gene, located on human chromosome 8, has three exons. It codes for transcription factor that regulates expression of many genes. c-MYC has a pivotal function in growth control, differentiation and apoptosis in cells. It is involved in regulation of cell metabolism through control of expression of genes involved in glucose and glutamine metabolism. Deregulated MYC oncogene produces transcription factor that alters global gene expression through transcriptional regulation, resulting in formation of typical tumor characteristics (uncontrolled growth, immortality, loss of contact inhibition...) and induction of tumorigenesis. MYC is overexpressed in a majority of human tumors, including malignant neoplasms of lymphoid, mesenchymal and epithelial origin.

Item Type: Thesis (Bachelor's thesis)
Supervisor: Korać, Petra
Date: 2015
Number of Pages: 15
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 14 Apr 2016 10:31
Last Modified: 14 Apr 2016 10:31
URI: http://digre.pmf.unizg.hr/id/eprint/4719

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