Treatment of chronic bacterial infections - new approach

Pernar, Margareta (2015) Treatment of chronic bacterial infections - new approach. Bachelor's thesis, Faculty of Science > Department of Biology.

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Abstract

Antibiotic resistance represents serious problem in todays medicine due to high mutation rate in bacteria. Less known, but not less important problem are persisters - dormant cells tolerant to antibiotic treatment. Persisters do not appear at a particular stage in the cell cycle, nor they are produced in response to antibiotics. Instead, persisters are rare nongrowing cells preexisting in a population. Persister cells the are main cause of chronic infections due to their ability to revive and restore bacterial population. Need to develope more efficient agent against persisters lead to ADEP antibiotics, and their derivative ADEP4. Unlike conventional antibiotics that kill bacteria by corrupting a cellular target that is active during bacterial growth, ADEPs activate the protease ClpP and causes it to become a more promiscuous enzyme, resulting in self-digestion of the bacteria’s proteins, leading to cell death (Figure 9). These results show high efficiency of ADEP in killing persistor cells, whereas its combination with rifampicin eradicates infection. Positive results that ADEP4 shows give basis for development of more efficient treatments for chronic bacterial infections. Furthermore, its general principle of killing may be applied to other organisms as well and prove effective in developing cure to treat fungal infections and cancer.

Item Type: Thesis (Bachelor's thesis)
Supervisor: Ivančić Baće, Ivana
Date: 2015
Number of Pages: 13
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 14 Apr 2016 11:21
Last Modified: 14 Apr 2016 11:21
URI: http://digre.pmf.unizg.hr/id/eprint/4731

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