Immunosuppression inhibitors in tumor therapy

Salar, Anamarija (2015) Immunosuppression inhibitors in tumor therapy. Bachelor's thesis, Faculty of Science > Department of Biology.

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Abstract

Immune system cells, which play an essential role in the defense against tumors are T-cells. Tumor cells use different mechanisms to prevent activation of T-cells, and thus an effective immune response of the body. Tumors may stimulate inhibitory signaling pathway molecules (CTLA-4 and PD-1) which are expressed on the surface of T-cells. CTLA-4 and PD-1 have different mechanisms of action; CTLA-4 prevents clonal multiplication of T cells and PD-1 limits the function of effector T-cells. By blocking the inhibitory receptor we can get effective antitumor response which can be used in immunotherapy. New drugs are actually monoclonal antibodies directed to tumor disarming defense in relation to our immune system. Studies have shown good results in the treatment of advanced melanoma, renal cancer and lung cancer. The most promising clinically evaluated drugs are ipilimumab (blockers of CTLA-4) and nivolumab (inhibitor of PD-1).

Item Type: Thesis (Bachelor's thesis)
Supervisor: Marijanović, Inga
Date: 2015
Number of Pages: 19
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 14 Apr 2016 13:53
Last Modified: 14 Apr 2016 13:53
URI: http://digre.pmf.unizg.hr/id/eprint/4744

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