Epigenetic reprogramming in primordial germ cells

Stipoljev, Sunčica (2015) Epigenetic reprogramming in primordial germ cells. Bachelor's thesis, Faculty of Science > Department of Biology.

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Abstract

The epigenetic profile of germ cells, which is defined by modifications of DNA and chromatin, changes dynamically during their development. At two points in the life cycle, DNA methylation marks are reprogrammed on a global scale, concomitant with restoration of developmental potency. DNA methylation patterns are subsequently re-established with the commitment towards a distinct cell fate. This reprogramming of DNA methylation takes place firstly on fertilization in the zygote, and secondly in primordial germ cells (PGCs), which are the direct progenitors of sperm or oocyte. In each reprogramming phase, a unique set of mechanisms regulates DNA methylation erasure and re-establishment. No studies are yet available on the full ontogeny of germline epigenetic reprogramming in the human and very few observations have been reported with regard to chromatin changes and DNA demethylation in PGCs. Indeed, a definitive timeline of when these events occur in humans has not been established (Leitch i sur., 2013).

Item Type: Thesis (Bachelor's thesis)
Supervisor: Lacković Venturin, Gordana
Date: 2015
Number of Pages: 15
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 14 Apr 2016 13:59
Last Modified: 14 Apr 2016 13:59
URI: http://digre.pmf.unizg.hr/id/eprint/4746

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