Bacterial group I introns

Vučetić, Adriana (2015) Bacterial group I introns. Bachelor's thesis, Faculty of Science > Department of Biology.

Language: Croatian

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Group I introns are intervening sequences that have invaded tRNA, rRNA and protein coding genes in bacteria and their phages, and are also found in the nuclear, chloroplast and mitochondrial genomes of eukaryotes. These introns interrupt RNA genes, and their splicing from precursor RNAs is catalyzed by acting as ribozymes, by folding to a well-defined three-dimensional structure. Efficient in vivo splicing of group I introns often requires interaction with cellular RNA-binding proteins or with intron-encoded factors that promote the formation of splicing-competent RNA structures. Some group I introns are mobile genetic elements due to encoded homing endonuclease (HEases) genes that promote their spread to intronless alleles. Group I introns have a limited distribution among bacteria and the current assumption is that they are phenotypically neutral, yet the co-opting of intron functions by a riboswitch or the domestication of intron-encoded homing endonuclease as a regulatory protein indicates that introns can be a source of genetic novelty. One of the most intriguing questions about mobile group I introns concerns their evolutionary origin. The current consensus is that HEases and group I introns had distinct evolutionary origins.

Item Type: Thesis (Bachelor's thesis)
Supervisor: Ivančić Baće, Ivana
Date: 2015
Number of Pages: 20
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 14 Apr 2016 14:28
Last Modified: 14 Apr 2016 14:28

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