Humanization of N- and O-glycosylated plant proteins

Zubčić, Klara (2015) Humanization of N- and O-glycosylated plant proteins. Bachelor's thesis, Faculty of Science > Department of Biology.

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Abstract

Glycan structures of therapeutic proteins affect their pharmacodynamics and pharmacokinetic characteristics. Optimal glycosylation would enhance efficiency and safety of recombinant pharmaceutical proteins. Due to inexpensive and simple cultivation, simple Nglycosylation pathway and absence of typical mammalian O-glycosylation pathway, in recent years plants have emerged as interesting new hosts for the production of fully humanized recombinant pharmaceutical proteins. Aims in engineering optimal expression system are inactivation of genes for plant-specific enzymes and introduction of enzymes that are humanspecific.

Item Type: Thesis (Bachelor's thesis)
Supervisor: Balen, Biljana
Date: 2015
Number of Pages: 11
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 14 Apr 2016 14:36
Last Modified: 14 Apr 2016 14:36
URI: http://digre.pmf.unizg.hr/id/eprint/4757

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