Cytogenetic and oxidative status of individuals with thyroid gland illnesses

Gerić, Marko (2016) Cytogenetic and oxidative status of individuals with thyroid gland illnesses. Doctoral thesis, Faculty of Science > Department of Biology.

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Abstract

Biomonitoring of genome integrity could be used for better cancer prevention. Thyroid cancer has become one of the fastest growing cancer types in the world. When compared to 100 matched controls, patients with thyroid illnesses showed higher basal DNA damage in peripheral blood lymphocytes (1.24-fold increase in sister chromatid exchanges, 1.47-fold increase in total number of chromosomal aberrations, 1.84-fold increase in tail intensity, and 2.32-fold increase in total number of micronuclei). The oxidative status of thyroid patients was also altered showing 1.60-fold increase in concentration of malondialdehyde and 32 % decrease in concentration of glutathione. Finally, the observed B-Raf and Ret in 97.89 % of patient’s tissue cytoplasms suggest that cytogenetic biomarkers could be used in thyroid cancer prevention. Additionally, oxidative stress might be one of the mechanisms of thyroid disease initiation.

Item Type: Thesis (Doctoral thesis)
Keywords: DNA damage, oxidative stress, thyroid gland, cancer, B-Raf, Ret
Supervisor: Garaj-Vrhovac, Vera and Šarčević, Božena
Date: 2016
Number of Pages: 121
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Grozdana Sirotic
Date Deposited: 05 Jul 2016 10:44
Last Modified: 05 Jul 2016 10:44
URI: http://digre.pmf.unizg.hr/id/eprint/4946

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