Antioxidant, antibacterial and cytotoxic activities and phytochemical screening of plant species Centaurea ragusina L.

Vujčić, Valerija (2016) Antioxidant, antibacterial and cytotoxic activities and phytochemical screening of plant species Centaurea ragusina L.. Doctoral thesis, Faculty of Science > Department of Biology.

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Abstract

Biological activity of Centaurea genus is mainly attributed to compounds of the terpenoid and flavonoid type which showed antioxidant, antimicrobial, cytotoxic and other therapeutic properties. The goal of this work was to determine polyphenol content and composition of phytochemicals in Croatian endemic plant species Centaurea ragusina L. collected at natural habitats, cultivated in vitro and acclimated plants as well as to estimate their antioxidant, antibacterial and cytotoxic activity. Ethanolic/aqueous extracts showed the highest level of total phenols, flavonoids and hydroxycinnamic acid. Ethanolic/aqueous and ethanolic/ethanolic extracts showed significant antioxidant activity regardless of the plant origin. Crude ethanolic/ethanolic extract of leaves, almost all tested fractions and two isolated sesquiterpene lactones showed significant antibacterial activity against Staphylococcus aureus ATCC 25923. All aqueous/aqueous extracts showed significant stabilisation effects of DNA and RNA. Almost all tested extracts and fractions CRE01_06-10 exhibited significant inhibitory activities against all tested cancer cell lines.

Item Type: Thesis (Doctoral thesis)
Keywords: Centaurea ragusina L., phytochemicals, biological activity, interactions with polynucleotides
Supervisor: Radić Brkanac, Sandra and Radić Stojković, Marijana
Date: 2016
Number of Pages: 123
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Grozdana Sirotic
Date Deposited: 05 Jul 2016 13:23
Last Modified: 05 Jul 2016 13:23
URI: http://digre.pmf.unizg.hr/id/eprint/4952

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