The toxicity and oxidative effects of Ginkgo formulation and antihemostatic drugs in rats

Skoko, Marija (2016) The toxicity and oxidative effects of Ginkgo formulation and antihemostatic drugs in rats. Doctoral thesis, Faculty of Science > Department of Biology.

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Abstract

The aim of this study was to demonstrate the effects and the differences in toxicity and prooxidant and antihemostatic mechanisms of three herbal dietary supplements, containing extract of Ginkgo biloba, that are available in Croatia. The goal was also to investigate their efect in combination with antihemostatic drugs, acetylsalicylic acid and warfarin. The study was conducted on animal model. Platelet aggregation and coagulation tests proved that all used herbal products prolong platelet aggregation, while on coagulation they had no statistically significant effect. It has been shown that the use of herbal dietary supplements in combination with medicaments changes the value of the measured biomarkers of oxidative stress, the activity of superoxide dismutase (SOD) and catalase and concentration of glutathione (GSH) and malondialdehyde (MDA) in tissues of liver, kidney, spleen and brain, and also in blood. The results suggested that the greater attention should be paid to the usage of these products in clinical practice.

Item Type: Thesis (Doctoral thesis)
Keywords: ginko, platelt agregation, hemostasis, antioxidant system, warfarin, acetilsalycilic acid
Supervisor: Đijić, Domagoj
Date: 2016
Number of Pages: 138
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Grozdana Sirotic
Date Deposited: 15 Jul 2016 09:39
Last Modified: 15 Jul 2016 09:39
URI: http://digre.pmf.unizg.hr/id/eprint/4978

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