Synthesis of peptidomimetics comprising hydrazino - derivatives of amino acides

Suć, Josipa (2016) Synthesis of peptidomimetics comprising hydrazino - derivatives of amino acides. Doctoral thesis, Faculty of Science > Department of Chemistry.

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Abstract

Peptides and proteins have a crucial role in a number of biological and physiological processes; however, their use as therapeutics is limited by poor stability and bioavailability. Therefore, the development of peptidomimetics, compounds that mimic structure and/or function of proteins is of great importance for the academic community and the pharmaceutical industry. The objective of the research proposed in this doctoral thesis is the preparation of peptidomimetics using hydrazino derivatives of α-amino acids. Therefore, studies include: development of methodologies for the preparation of optically pure hydrazino derivatives of α-amino acids; development of methodology for the preparation of hydrazino peptidomimetics by stepwise synthesis in solution and by multicomponent reactions. Expected results are: optimized conditions for the preparation of hydrazino derivatives of α-amino acids and hydrazino peptidomimetics and a new class of peptidomimetics comprising hydrazino moiety.

Item Type: Thesis (Doctoral thesis)
Keywords: hydrazino derivatives of α-amino acids, hydrazino depsipeptides, hydrazino peptidomimetics, multicomponent reactions
Supervisor: Jerić, Ivanka
Date: 2016
Number of Pages: 191
Subjects: NATURAL SCIENCES > Chemistry
Divisions: Faculty of Science > Department of Chemistry
Depositing User: Branka Maravic
Date Deposited: 08 Sep 2016 11:25
Last Modified: 08 Sep 2016 11:25
URI: http://digre.pmf.unizg.hr/id/eprint/5044

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