Regeneration of zebrafish (Danio rerio, F. Hamilton, 1822)

Miljković, Frane (2016) Regeneration of zebrafish (Danio rerio, F. Hamilton, 1822). Bachelor's thesis, Faculty of Science > Department of Biology.

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Abstract

The limited regenerative capacity of several organs, such as central nervous system (CNS), heart and limb in mammals makes related major diseases quite difficult to recover. Therefore, knowledge of the cellular and molecular mechanisms underlying organ regeneration is of great scientific and clinical interests. Tremendous progression has already been made after extensive investigations using several model organisms for decades. Unfortunately, distance to the final achievement of the goal still remains. Recently, zebrafish became a popular model organism for the deep understanding of regeneration based on its powerful regenerative capacity, in particular the organs that are limitedly regenerated in mammals. Additionally, zebrafish are endowed with other advantages good for the study of organ regeneration. This review summarizes the recent progress in the study of zebrafish organ regeneration, in particular regeneration of fin, heart, CNS, and liver. There are also discussions about reasons of the reduced regenerative capacity in higher vertebrates, the roles of inflammation during regeneration, and the difference between organogenesis and regeneration.

Item Type: Thesis (Bachelor's thesis)
Supervisor: Lacković-Venturin, Gordana
Date: 2016
Number of Pages: 17
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Grozdana Sirotic
Date Deposited: 24 Oct 2016 11:47
Last Modified: 24 Oct 2016 11:47
URI: http://digre.pmf.unizg.hr/id/eprint/5223

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