Cell lines in cancer research

Hribljan, Valentina (2016) Cell lines in cancer research. Bachelor's thesis, Faculty of Science > Department of Biology.

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Abstract

Cancer cell lines are the most widely used models in cancer research. They are fast-growing cells, easy to handle compared to other cancer models and there is huge variety of different kinds in cell line banks. Other models have their advantages, e.g. animal models can be used for studying cancer progression. Therefore, to understand the complete picture of tumorogenesis it is the best to combine different models. Conditions in cell culture determine the genotype and therefore also phenotype of cells so it is important to optimise cell culture conditions in order to get cancer cell lines that will be representative models in cancer research. They are main models for preclinical drug testing - over 1000 different cell lines represent cancer diversity and enable personalized treatment approach. The most widely used cell lines are not necessary the best models. The Cancer Genome Atlas and Cancer Cell Line Encyclopedia enable comparison of genomic profiles of cancer cell lines and tumors in vivo in order to find cell lines that are the most relevant for certain research. Cancer cell lines can be used in other researches such as testing toxicity of some agents. Some cancer cell lines can be used as in vitro model for cancer stem cell research – model for new potential targets of drug treatment.

Item Type: Thesis (Bachelor's thesis)
Supervisor: Korać, Petra
Date: 2016
Number of Pages: 22
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Grozdana Sirotic
Date Deposited: 26 Oct 2016 12:39
Last Modified: 26 Oct 2016 12:39
URI: http://digre.pmf.unizg.hr/id/eprint/5245

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