Intrinsically disordered proteins

Tomljanović, Ingrid (2016) Intrinsically disordered proteins. Bachelor's thesis, Faculty of Science > Department of Biology.

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Abstract

Intrinsically disordered proteins and protein regions (IDP/IDR) are a recently recognized group of proteins which are biologically active despite their inherent lack of a well-defined three-dimensional structure. Unlike globular proteins, IDPs lack a unique and stable 3D structure in their native state and exist as fluctuating ensembles of conformations which are well-suited for cellular signaling, regulation, chaperone activity, disease pathogenesis and other various functions. The aim of this Bachelor’s thesis is to describe the main characteristics of IDPs and the most important experimental and bioinformatic methods used in IDP research. Moreover, the thesis includes a classification of IDPs according to functional mechanism and cellular role, as well as a brief section on IDPs in plants in normal and stressful conditions. In conclusion, the IDP field has witnessed rapid growth in the past two decades and, based on the abundance and wide spread of these proteins, there is significant potential for future research within this field.

Item Type: Thesis (Bachelor's thesis)
Supervisor: Pavoković, Dubravko
Date: 2016
Number of Pages: 19
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Grozdana Sirotic
Date Deposited: 26 Oct 2016 12:48
Last Modified: 26 Oct 2016 12:48
URI: http://digre.pmf.unizg.hr/id/eprint/5247

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