Intracellular moonlighting proteins on the cell surface

Funtak, Kristina (2016) Intracellular moonlighting proteins on the cell surface. Bachelor's thesis, Faculty of Science > Department of Biology.

Language: Croatian

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Moonlighting proteins comprise a subset of multifunctional proteins that perform two or more biochemical functions, that are not due to gene fusion, alternative splicing, proteolytic fragments or promiscuous enzymes activities. Intracellular proteins that moonlight on the cell surface have been identified by chance in proteomic researches. The number of new MPCSs is growing, and therefore their primary and secondary functions, differences with intracellular proteins, and possible similarities with extracellular proteins were investigated. Although we know some mechanism more elaborate, as the receptor for plasminogen, many of MPCSs has unknown or unexplained functions. The bioinformatics progresses allow faster and precise identification of the MPCSs, which could lead to discovery of a larger number of MPCSs, and to understanding of their evolution. One hypothesis is that gene duplication may have a role in the origin of the MPCSs, but it does not have to be the only explanation. Extensive and systematic experiments will allow better understanding of the evolution and the features of MPCSs.

Item Type: Thesis (Bachelor's thesis)
Supervisor: Balen, Biljana
Date: 2016
Number of Pages: 15
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Grozdana Sirotic
Date Deposited: 09 Nov 2016 10:59
Last Modified: 09 Nov 2016 10:59

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