Analysis of multielement profile, aminoacids and vasopressin in suicide attempters with major depression disorder

Drmić, Stipe (2016) Analysis of multielement profile, aminoacids and vasopressin in suicide attempters with major depression disorder. Doctoral thesis, Faculty of Science > Department of Biology.

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Abstract

Most of the suicides and suicide attempts are result of depressive disorders. Due to a pandemic increase of such disorders, most suicides and suicide attempts are committed by depressive persons, reliable biomarkers of the suicide risk are needed. Measurement of elements concentration in specific biological samples gives us an insight into metabolic dynamic change in normal and pathological processes. Metabolic status of bioelements as well as hormones and amino acids levels could be the biomarkers of suicidal behavior.The aim of research was to analyze concentracions of electrolytes and trace elements, plasma amino acids and vasopressin in depressed hospitalized suicide attempters (n=38) and to correlate the results with those in control subjects (n=47). The main hypothesis of this research was that there is a significant difference in above mentioned parameters between suicide attempters with major depression disorder and healthy control subjects. Significantly higher concentration of sodium (Na) has not been observed in suicide attempter group. Suicide risk increases with decreased or average concentration of iodine (I) and lithium (Li), increased or average concentration of barium (Ba) as well as the age > 43.5 years. We determined significantly decreased concentration of asparagine in suicide attempters. Negative correlation between arginine vasopressin and suicidal behaviour was found (p<0,001). This study could be the basis for potential development of neuro-specific biomarkers in personalized medicine.

Item Type: Thesis (Doctoral thesis)
Keywords: bioelements, aminoacids, vasopressin, suicide, depression, asparagine
Supervisor: Mimica, Ninoslav
Date: 2016
Number of Pages: 115
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Grozdana Sirotic
Date Deposited: 11 Jan 2017 12:37
Last Modified: 11 Jan 2017 12:37
URI: http://digre.pmf.unizg.hr/id/eprint/5399

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