Gene polymorphisms of the apolipoprotein A5 and the fatty acid-binding protein 2 in the metabolic syndrome of the elderly subjects

Feher Turković, Lana (2016) Gene polymorphisms of the apolipoprotein A5 and the fatty acid-binding protein 2 in the metabolic syndrome of the elderly subjects. Doctoral thesis, Faculty of Science > Department of Chemistry.

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Abstract

Metabolic syndrome (MetS) is a multifactorial disorder. Among the risk factors for developing MetS are dyslipidemia, abdominal obesity, hypertension and hyperglycemia. The other risk factors include also the genetic factors. To determine whether changes in the structure of the gene for apolipoprotein A5 (ApoA5) and the fatty acid-binding protein 2 (FABP2), that participate in the extracellular / intracellular transport of lipids influence the occurrence of MetS in older population, an investigation was conducted on 345 subjects, males and females, aged 70-93 years. For each subject were determined the anthropometric values. The concentrations of glucose, total protein and C-reactive protein were determined in serum by biochemical methods. Genotyping of selected genes was carried out by methods based on the polymerase chain reaction. The composition and concentration of fatty acids in subjects with and without MetS were determined by gas chromatography. Statistical analysis showed that genetic variants of ApoA5 gene and FABP2 gene were not associated with an increased risk for developing metabolic syndrome. However, ApoA5 and FABP2 gene polymorphisms may be associated with serum lipid levels in an elderly population with MetS. The conclusion is that the ApoA5 and FABP2 could be considered as factors for pathobiochemistry of multifactorial disorders such as MetS.

Item Type: Thesis (Doctoral thesis)
Keywords: ApoA5, FABP2, metabolic syndrome, gene polymorphisms
Supervisor: Pašalić, Daria
Date: 2016
Number of Pages: 164
Subjects: NATURAL SCIENCES > Biology > Biochemistry and Molecular Biology
Divisions: Faculty of Science > Department of Chemistry
Depositing User: Branka Maravic
Date Deposited: 16 Jan 2017 17:19
Last Modified: 16 Jan 2017 17:19
URI: http://digre.pmf.unizg.hr/id/eprint/5415

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