Genetics of colon cancer

Brezak, Matea (2016) Genetics of colon cancer. Bachelor's thesis, Faculty of Science > Department of Biology.

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Abstract

Colorectal cancer is a malignant epithelial tumor and one of the most common forms of malignancies that affect both man and women. Despite high rate of mortality, incidence of this cancer is decreasing, but still represents a major health issue. According to the origin, it can be divided into family, hereditary and sporadic form. By studying hereditary syndromes such as FAP and HNPCC, mutations in APC, MMR, KRAS and p53 genes are found. Mutations of these genes are part of cancerogenesis in sporadic forms of colorectal cancer as well as in hereditary syndromes. With development of research methods some less common syndromes and mutations in associated genes have been discovered. Mechanisms of carcinogenesis were understood by studying EpCAM, MUTYH, SMAD4 and STK-11 genes that are included in development of rare syndromes and previously discovered mutations of diferent genes. Research of its carcinocenesis has contributed to development of more precise treatment methods. Despite the significant number of newly discovered mutated genes, it is necessary to continue research in this field to understand the nature and significance of the colon cancer cancerogenesis.

Item Type: Thesis (Bachelor's thesis)
Supervisor: Korać, Petra
Date: 2016
Number of Pages: 19
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Palma Dizdarevic
Date Deposited: 04 May 2017 10:05
Last Modified: 04 May 2017 10:11
URI: http://digre.pmf.unizg.hr/id/eprint/5492

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