Hypoxia/ischemia and physiological solutions in animals

Medaković, Nikolina (2016) Hypoxia/ischemia and physiological solutions in animals. Bachelor's thesis, Faculty of Science > Department of Biology.

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Abstract

The primary condition for the health of human body cells is supply of oxygen through a chemical process that becomes a source of energy necessary for the maintenance of their life. Oxygen is the main source of energy for the brain and other organs. Many,but certainly not all, types of neurons are rapidly killed by lack of oxygen. However,there are naturally hypoxia-tolerant neurons. The naturally anoxia-tolerant neurons from several species of animals may offer unparalled opportunities to identify strategies that might be employed to enhance the hypoxia or ischemia tolerance of vulnerable neurons. Perhaps the best characterized hypoxia-tolerant neurons are those from the freshwater turtle genus Chrysemys and fish crucian carp (Carassius carassius). The turtle and carp brain can withstand prolonged periods of severe hypoxia without displaying any change in cellular ATP levels and induction of membrane depolarization that cause the death of neurons of mammals. Hypoksia-tolerant neurons of turtle and crucian carp detect decreases in oxygen and create signals that lead to a decrease in condcutance of ion channels (ion flux arrest), pruduction of energy (metabolic arrest) and slowly activate specific genes. Furthemore, studies have shown that hypoxia-induced supression of NMDA receptors in turtle neurons may bi critical for surviving months of anoxic dormancy. Although the turtle and carp brain are extremely hypoxia tolerant, they are sensitive to ischemia like mammalian brain. Finally, it is necessary to carry out a large number of research in devising new strategies for neuroprotection during diseases associated with hypoxic and ischeamic conditions.

Item Type: Thesis (Bachelor's thesis)
Supervisor: Lisičić, Duje
Date: 2016
Number of Pages: 22
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Palma Dizdarevic
Date Deposited: 05 May 2017 07:59
Last Modified: 05 May 2017 07:59
URI: http://digre.pmf.unizg.hr/id/eprint/5506

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