The level of expression of transcription factor LEF-1 in glioblastomas

Sukser, Viktorija (2013) The level of expression of transcription factor LEF-1 in glioblastomas. Diploma thesis, Faculty of Science > Department of Biology.

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Abstract

Glioblastomas are the most common and most aggressive brain tumours in adults, and are classified as grade IV astrocytoma by the criteria of the World Health Organization. They can develop either de novo (primary) or from a lower-grade astrocytoma (secondary). Each type has its own characteristic genetic changes. Among the signalling pathways affected by these disorders is the Wnt pathway, which is important during normal embryonic development, as well as in stem cells. The key molecule in this pathway is β-catenin: when signals are absent, it is degraded, and when the Wnt pathway is activated, then β-catenin enters the nucleus and binds to transcription factors of the TCF/LEF family. One of its members is LEF-1 (lymphoid enhancer factor-1) which, together with β-catenin, drives the transcription of many genes that, if the signalling is aberrant, contribute to progression and invasiveness of the tumour. This study analyses the level of expression of LEF-1 in glioblastoma tissue samples. With the use of immunohistochemical methods, protein LEF-1 was localized in the cells' nuclei and its expression was found to be elevated in 80,6% of analyzed samples.

Item Type: Thesis (Diploma thesis)
Keywords: transcription factor LEF-1; glioblastoma; Wnt pathway
Supervisor: Pećina-Šlaus, Nives
Co-supervisor: Hranilović , Dubravka
Date: 2013
Number of Pages: 52
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Grozdana Sirotic
Date Deposited: 11 Mar 2014 18:07
Last Modified: 07 Oct 2014 08:17
URI: http://digre.pmf.unizg.hr/id/eprint/573

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