Dynein, microtubule and cargo: a ménage à trois

Pavin, Nenad and Tolić‑Nørrelykke, Iva M. (2013) Dynein, microtubule and cargo: a ménage à trois. Biochemical Society Transactions, 41 (6). pp. 1731-1735.

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To exert forces, motor proteins bind with one end to cytoskeletal filaments, such as microtubules and actin, and with the other end to the cell cortex, a vesicle or another motor. A general question is how motors search for sites in the cell where both motor ends can bind to their respective binding partners. In the present review, we focus on cytoplasmic dynein, which is required for a myriad of cellular functions in interphase, mitosis and meiosis, ranging from transport of organelles and functioning of the mitotic spindle to chromosome movements in meiotic prophase. We discuss how dynein targets sites where it can exert a pulling force on the microtubule to transport cargo inside the cell.

Item Type: Article
Keywords: cargo, cortical anchor, dynein, microtubule. motor protein, targeting
Date: 2013
Subjects: NATURAL SCIENCES > Biology
Additional Information: © 2013 The author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial Licence (http://creativecommons.org/licenses/by-nc/2.5/) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited.
Divisions: Faculty of Science > Department of Physics
Depositing User: Gordana Stubičan Ladešić
Date Deposited: 05 Mar 2019 16:41
Last Modified: 05 Mar 2019 16:41
URI: http://digre.pmf.unizg.hr/id/eprint/5877

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