Polymorphisms of the 5-HT2C receptor and APOE genes in patients with Alzheimer's disease

Baričević, Andreja (2012) Polymorphisms of the 5-HT2C receptor and APOE genes in patients with Alzheimer's disease. Diploma thesis, Faculty of Science > Department of Biology.

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Alzheimer's disease (AD) is a neurodegenerative disorder characterized by degeneration of the neurons in cortical and subcortical brain regions. Neurodegeneration affects the neurons that synthesize neurotransmitters like serotonin. Our hypothesis was that genetic variants of serotonergic receptor type 2C (5-HT2C) and apolipoprotein E (APOE) are risk factors for the development of AD. The aim of the study was to determine polymorphism (rs3813929; -759C/T) of 5-HT2C gene and APOE (rs7412 and rs429358) gene in 366 healthy elderly persons and 207 patients with AD. Results showed: a) no difference in genotype and allele frequencies of -759C/T 5-HT2C gene polymorphism between patients and healthy controls, b) the significant increase in allele E4 frequency in patients with AD, c) no sinergistic effect of these genes. Our results confirm that alele E4 could be a risk factor for AD, but do not support the hypothesis that polymorphism of 5-HT2C receptor gene is related to AD.

Item Type: Thesis (Diploma thesis)
Keywords: Alzheimer's disease, APOE, 5-HT2C receptor, polymorphism
Supervisor: Mück-Šeler, Dorotea
Co-supervisor: Hranilović, Dubravka
Date: 2012
Number of Pages: 54
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Grozdana Sirotic
Date Deposited: 14 Mar 2014 11:23
Last Modified: 28 Apr 2017 09:15
URI: http://digre.pmf.unizg.hr/id/eprint/589

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