Association of the human leukocyte antigen region with renal carcinoma

Kutle, Ivana (2012) Association of the human leukocyte antigen region with renal carcinoma. Diploma thesis, Faculty of Science > Department of Biology.

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In this study, we analyzed HLA-A, -B and -DRB1 genes and alleles and TNFa, TNFb and TNFd microsatellite alleles among 62 unrelated patients with renal carcinoma. No statistically significant difference was found in HLA genes and alleles frequency among patients with renal carcinoma in comparison to controls. Comparison which took into account size, tumor gradus and lymph node metastasis, revealed differences in the frequency of HLA-B*27 (p=0.0073), -DRB1*12 (p=0.0492) and -B*08 (p=0.0441) but only before the p value correction. Patients with gradus 4 showed a significant increase of HLA-DRB1*13 frequency (p=0.0394) in comparison to controls and patients with gradus 2 and 3 even after p value correction. There was no difference in the frequency of TNFa and TNFd alleles among patients in comparison to controls as opposed to TNFb locus for which a higher frequency of TNFb-5 (p=3.7X10-7), and reduced frequency of TNFb-3 (p=0.0002) among patients was observed. TNFb-5 allele occurs more frequently in patients with tumors >7 cm and gradus 4, while the frequency of TNFb-3 in both subgroups shows a decrease compared to controls. The observed difference leads to conclusion that TNFb-5 could infer susceptibility and TNFb-3 protection in the development of renal carcinoma.

Item Type: Thesis (Diploma thesis)
Keywords: microsatellite, HLA alleles, HLA genes, TNF cytokine, renal carcinoma
Supervisor: Grubić, Zorana
Date: 2012
Number of Pages: 54
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Grozdana Sirotic
Date Deposited: 14 Mar 2014 12:09
Last Modified: 14 Mar 2014 12:09

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