Autotransplantation of rat skin cells

Kralj, Ines (2014) Autotransplantation of rat skin cells. Diploma thesis, Faculty of Science > Department of Biology.

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Abstract

Aging is a process that progressively affects all organs and organ systems. One of widely used models in study of aging is skin and in this paper we used rat as a model. Studies have shown accumulation of senescent cells to be the main cause of changes that occur with aging. To test this hypothesis, it is necessary to develop a method for changing composition of skin cells. Many questions need to be answered, such as the ability of cells to incorporate into tissue after reimplantation, whether the number and density of reimplanted cells is sufficient to induce proper effect and whether their frequency allows detection and analysis. Results show that re-implanted cells after isolation and labeling effectively implant in dorsal skin of rats in a significant percentage of almost 6 %. This opens up the possibility of significantly affecting physiology and skin texture but also of wider experimental and potentially therapeutic applications.

Item Type: Thesis (Diploma thesis)
Keywords: cell autotransplantation, skin, microseeding, DiI
Supervisor: Rubelj, Ivica
Date: 2014
Number of Pages: 49
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Grozdana Sirotic
Date Deposited: 19 Mar 2014 08:59
Last Modified: 19 Mar 2014 08:59
URI: http://digre.pmf.unizg.hr/id/eprint/630

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