Genotyping of families with obsessive-compulsive disorder

Čonda, Martina (2014) Genotyping of families with obsessive-compulsive disorder. Diploma thesis, Faculty of Science > Department of Biology.

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Obsessive-compulsive disorder (OCD), a neuropsychiatric disorder, is characterized by the presence of obsessions and/or compulsions. According to previous publications association of genetic variations in glutamatergic genes with OCD are considered that may potentially contribute to the pathophysiology of OCD. The main aim of this thesis was to provide confirmatory evidence for association of five selected single nucleotide polymorphism (SNP); rs301443 (G/C), rs12682807 (A/C), rs11081062 (C/T), rs11663827 (A/G) and rs1556995 (G/A) from a three glutamatergic candidate genes; SLC1A1, DPGAP1, GRIK2 with early-onset OCD using family-based study and case-control study. The current study could not confirm the previous findings of these three candidate genes as risk variants in early-onset OCD.

Item Type: Thesis (Diploma thesis)
Keywords: arly-onset, glutamate, SLC1A1, DLGAP1, GRIK2, polymorphisms
Supervisor: Grünblatt, Edna
Co-supervisor: Đikić, Domagoj
Date: 2014
Number of Pages: 65
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Grozdana Sirotic
Date Deposited: 19 Mar 2014 09:34
Last Modified: 23 Sep 2014 10:28

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