Association of leptin gene and leptin receptor polymorphisms with obesity in humans

Petrić, Sara (2013) Association of leptin gene and leptin receptor polymorphisms with obesity in humans . Diploma thesis, Faculty of Science > Department of Biology.

[img] PDF
Restricted to Registered users only
Language: Croatian

Download (1MB) | Request a copy

Abstract

Obesity is complex disorder which develops when energy intake exceeds energy utilization. It increases the risk for a variety of chronic diseases. The leptin-signalling pathway is considered one of the most important routes involved in energy homeostasis. Leptin is a hormone produced predominantly by the white adipose tissue. Leptin receptor is expressed in many tissues, but it is particularly important in the hypothalamus, where it regulates energy homeostasis (food intake and energy expenditure). Many leptin and leptin receptor genes polymorphisms have been investigated, and some of them are candidates for association with obesity. In this study, leptin receptor polymorphisms Gln223Arg and Lys109Arg, and 27 leptin promoter polymorphisms have been analysed for association with obesity, in 375 Croatian Roma DNA samples. The results indicate that there is no association between Gln223Arg, and leptin promoter polymorphisms with obesity. However, Lys109Arg AA genotype is associated with overweight in men.

Item Type: Thesis (Diploma thesis)
Keywords: body mass index, overweight, Roma, SNP
Supervisor: Peričić Salihović, Marijana
Date: 2013
Number of Pages: 50
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Grozdana Sirotic
Date Deposited: 25 Mar 2014 11:50
Last Modified: 27 Apr 2017 12:17
URI: http://digre.pmf.unizg.hr/id/eprint/699

Actions (login required)

View Item View Item

Nema podataka za dohvacanje citata