Ser310Ala functional polymorphism in the GluR7 ionotropic glutamate receptor subunit gene (GRIK3) and development of alcohol dependence

Kuzman, Boris (2014) Ser310Ala functional polymorphism in the GluR7 ionotropic glutamate receptor subunit gene (GRIK3) and development of alcohol dependence. Diploma thesis, Faculty of Science > Department of Biology.

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Abstract

There is accumulating data suggesting an involvement of glutamate in the acute and chronic effects of alcohol, including dependence and withdrawal, and glutamatergic system is emerging as potential target for alcoholism treatment. Recent studies have suggested an association of ionotropic glutamate receptor genes with alcohol dependence. The aim of this study was to examine the association of Ser310Ala functional polymorphism (rs6691840) in the GluR7 glutamate kainate receptor subunit gene (GRIK3) with the development of alcoholism. The study included 275 alcohol-dependent patients and 208 healthy subjects. Possible differences in the frequency of GRIK3 genotypes and alleles between subjects of different gender and smoking status, as well as between alcohol-dependent patients stratified according to aggressive and suicidal behavior, age of drinking onset, and type of alcoholism according to Cloninger’s classification were also studied. The results demonstrated lower frequency of homozygous CC genotype in patients who started abusing alcohol before 25. years of age in relation to alcohol-dependent subjects with the late onset of alcohol abuse. Further studies are needed to elucidate the role of GRIK3 gene in the development of alcohol dependence.

Item Type: Thesis (Diploma thesis)
Keywords: alcoholism, glutamate kainate receptor, GRIK3 gene, polymorphism, rs6691840
Supervisor: Švob Štrac, Dubravka
Co-supervisor: Đikić, Domagoj
Date: 2014
Number of Pages: 58
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Grozdana Sirotic
Date Deposited: 25 Mar 2014 11:57
Last Modified: 23 Sep 2014 09:15
URI: http://digre.pmf.unizg.hr/id/eprint/700

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