Genetic structure of Croatian Roma population – analyses of leptin system genes’ polymorphisms

Ivankov, Ana-Maria (2014) Genetic structure of Croatian Roma population – analyses of leptin system genes’ polymorphisms . Diploma thesis, Faculty of Science > Department of Biology.

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Abstract

Humans inhabit different geographic locations characterized by different climate. Genotypic and phenotypic differences between populations were created by adaptation to different conditions. Climate influenced the frequency of genetic variants involved in metabolic pathways. Leptin system is recognized as important regulator of metabolism. Its compounds are hormone leptin and leptin receptor. Leptin is involved in the regulation of food intake and energy consumption via the hypothalamus, because its increased concentrations reduce appetite and stimulate energy expenditure. In this study 29 SNPs associated with leptin system are genotyped in Croatian Roma population. Allelic frequencies of these loci are compared between Romani and other worldwide populations. The resulting genetic distance between Roma and other populations suggests that the Romani gene pool originated as a result of genetic exchange between Asian and European populations. Also, statistically significant correlation exists between latitude, as proxy for climate, and the distribution of alleles of seven polymorphic loci between populations.

Item Type: Thesis (Diploma thesis)
Keywords: SNP, LEP, LEPR, selection, genetic drift
Supervisor: Peričić Salihović, Marijana
Date: 2014
Number of Pages: 48
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Grozdana Sirotic
Date Deposited: 25 Mar 2014 13:03
Last Modified: 25 Mar 2014 13:03
URI: http://digre.pmf.unizg.hr/id/eprint/702

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