Start/stop Codon-like Trinucleotides (CLTs) and Extended Clusters as New Language of DNA

Rosandić, Marija and Glunčić, Matko and Paar, Vladimir (2011) Start/stop Codon-like Trinucleotides (CLTs) and Extended Clusters as New Language of DNA. Croatica Chemica Acta, 84 (2). pp. 331-341. ISSN 0011-1643

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DNA nucleotide sequences carry genetic information of different kinds, not just coding instructions for protein synthesis. They can play a role, for example, in alternative conformations and gene regulators. The present paper introduces the extended start/stop codon-like trinucleotides (CLTs) for noncoding DNA sequences, based on trinucleotide cluster extension generated by specific single-nucleotide multiplications. Extended cluster analysis gives rise to rich information potential as a "new language" of DNA ("CLT-language"). The analysis of start/stop-CLTs extended clusters provides qualitative and quantitative differentiation and characterization of alpha satellites, as well as of other repetitive and non-repetitive noncoding sequences. As a measure of CLT extension of DNA sequences the extension factor r is introduced. Start/stop CLTs enable a distinction of three segments within alpha satellite, the first and the second as wrapping sequences and the third as a linker. Within a linker there are no start/stop CLTs. On the basis of start/stop-CLTs, it is hypothesized that these noncoding sequences may be involved in the networks of gene regulators.

Item Type: Article
Keywords: alpha satellites, start/stop codons, nucleosome, cluster extension, gene regulators
Date: 2011
Subjects: BIOMEDICINE AND HEALTH CARE > Basic Medical Sciences > Human Genetics, Genomics and Proteomics
Divisions: Faculty of Science > Department of Physics
Project code: 119-0982464-1253
Publisher: Hrvatsko kemijsko društvo
Depositing User: Gordana Stubičan Ladešić
Date Deposited: 23 Apr 2014 18:31
Last Modified: 24 Feb 2016 15:26

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